| Product Name | Plasmodium falciparum Circumsporozoite Protein, (6NANP) PfCSP |
| Purity | HPLC>95% |
| Description | P. falciparum circumsporozoite protein (PfCSP) is the most abundant antigen expressed on the surface of P. falciparum sporozoites. The middle part of the pre-erythropoiesis antigen contains 6 highly conserved immunodominant tetrapeptide repeats (NANP), and its N-terminal and C-terminal regions contain two key protection regions, respectively called RI and RII-plus . Both play a key role during the parasite invasion. PfCSP has always been the main target antigen in the development of pre-erythrocyte malaria vaccines, including subunit proteins with adjuvant or attenuated viral platforms. Studies have shown that high-titer antibodies against PfCSP are believed to block the invasion of blood-borne sporozoites on liver cells, thereby eliminating the development of blood-stage malaria. |
| Storage | -20°C |
| References | Zhang, Q. et al. Appl. Microbio. Biotech. 10, 1294 (2007). |
| Molecular Weight | 2499.6 |
| Sequence (One-Letter Code) | NANPNANPNANPNANPNANPNANPC |
| Sequence (Three-Letter Code) | H - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Cys - OH |
Plasmodium falciparum Circumsporozoite Protein, (6NANP) PfCSPAdmin2021-01-17T09:22:01+00:00
