| Product Name | Gamma - Fibrinogen (377-395) |
| Purity | HPLC>95% |
| Description | This fibrinogen-derived inhibitory peptide attenuates microglia activation and suppresses relapsing paralysis in multiple sclerosis (MS). Fibrinogen is a regulator of microglia activation and interaction of fibrinogen with the microglia integrin receptor Mac-1. Because blocking fibrinogen–Mac-1 interactions affects the pro-inflammatory but not the pro-coagulant properties of fibrinogen, targeting this gamma- fibrinogen epitope could represent a potential therapeutic strategy for MS and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation. |
| Storage | -20°C |
| References | Adams, R. et al. J. Exp. Med. Published online 5 March 2007 doi:10.1084/jem.20061931 |
| Molecular Weight | 2229.7 |
| Sequence (One-Letter Code) | YSMKETTMKIIPFNRLSIG |
| Sequence (Three-Letter Code) | H - Tyr - Ser - Met - Lys - Glu - Thr - Thr - Met - Lys - Ile - Ile - Pro - Phe - Asn - Arg - Leu - Ser - Ile - Gly - OH |
Gamma – Fibrinogen (377-395)Admin2021-01-05T04:34:26+00:00
