| Product Name | [Pyr3]-beta-Amyloid (3-40), Human |
| Purity | HPLC>95% |
| Description | This peptide triggers the formation of insoluble Aß peptide deposits, inhibits secretion of amyloid protein precursor (APP) and increases cell-associated APP. The fibrils in the plaques formed in the brains of patients with Alzheimer’s disease contain significant amounts of truncated Aß proteins such as Aß(3-40) and Aß (11- 40). These two fragments contain an N-terminal pyroglutamic acid. The g-carboxy group of glutamic acid forms a cyclic bond with the free N-terminal amino group to form pyroglutamate. |
| Storage | -20°C |
| References | Mok, SS. et al. J. Neurosci. Res. 61, 449 (2000); Russo, C. et al. Nature. 405, 531 (2000). |
| Molecular Weight | 4125.7 |
| Sequence (One-Letter Code) | Pyr-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV |
| Sequence (Three-Letter Code) | Pyr - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Val - Gly - Asp - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - OH |
[Pyr3]-beta-Amyloid (3-40), HumanAdmin2020-12-18T13:22:29+00:00
