| Product Name | [Gly21]-beta-Amyloid (1-40), A21G, Flemish Mutation, Human |
| Purity | HPLC>95% |
| Description | This peptide is the mutant form of the b-Amyloid peptide (1-40). The mutation within the coding region of the ß-Amyloid precursor protein (APP) results in substitution of glycine for alanine in this peptide. Presenile dementia is present in a pattern consistent in the family of British origin with the dominant inheritance of Flemish APP mutation. The impact of the point mutation A21G on b-Amyloid structure and dynamics varies from b-Amyloid (1-40) to b-Amyloid (1-42). |
| Storage | -20°C |
| References | Brooks, W. et al. Neurol. 63, 1613 (2004); Van Nostrand, W. et al. J. Biol. Chem. 276, 32860 (2001); A. Huet and P. Derreumaux Biophys. J. 91, 3829 (2006). |
| Molecular Weight | 4315.9 |
| Sequence (One-Letter Code) | DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVV |
| Sequence (Three-Letter Code) | H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Gly - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - OH |
[Gly21]-beta-Amyloid (1-40), A21G, Flemish Mutation, HumanAdmin2020-12-18T13:18:59+00:00
