| Product Name | Amyloid β-Protein (1-14) |
| Purity | HPLC>95% |
| Description | The N-terminal Aβ fragments Aβ1-14, Aβ1-15, and Aβ1-16 are elevated in cell media and in CSF in response to γ-secretase inhibitor treatment. The presence of these small peptides is consistent with a catabolic amyloid precursor protein cleavage pathway by β- followed by α-secretase. It has been shown that Aβ1-14, Aβ1-15, and Aβ1-16 increase dose-dependently in response to γ-secretase inhibitor treatment while Aβ1-42 levels are unchanged. |
| Storage | -20°C |
| References | E.Portelius et al., Neurodegener. Dis., 10, 138 (2012) E.Portelius et al., Curr. Pharm. Des., 17, 2594 (2011) E.Portelius et al., Alzheimer Res. Ther., 2, 7 (2010) |
| Molecular Weight | 1698.73 |
| Sequence (One-Letter Code) | DAEFRHDSGYEVHH |
| Sequence (Three-Letter Code) | H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-OH |
Amyloid β-Protein (1-14)Admin2020-12-18T12:33:39+00:00
