| Product Name | Tau (195-209) Heavy |
| Purity | HPLC>95% |
| Description | Amino acids 195-209 of the tubulin-related unit (tau). This region represents the tau trypsin peptide and is part of the core of the tau protein. Tau is a phosphoprotein involved in the assembly and stability of microtubules (MT) and brain development. Tau is phosphorylated by a variety of protein kinases at multiple sites, including cyclic AMP-dependent protein kinase and type 1 casein kinase. Tau phosphorylation causes tau to change shape, thereby negatively modulating its ability to stimulate MT assembly. Tau is also glycosylated, and O-glycosylation may play a role in its subcellular localization and degradation. The malfunctioning tau protein contributes to the structural core of the paired helical filaments (PHF) that make up the neurofibrillary tangles (NFT). NFT is frequently observed in neurodegenerative diseases such as Alzheimer's disease and other diseases. Tau is expressed by a single gene and is spliced into the adult central nervous system (CNS) to produce six different subtypes. The arginine residue at position 15 of the peptide is isotopically labeled with carbon 13 (6) and nitrogen 15 (4) isotopes. Compared with the unlabeled peptide, the mass of the peptide is increased by 10 |
| Storage | -20°C |
| References | Gendreau and Hall (2013) Tangles, Toxicity, and Tau Secretion in AD – New Approaches to a Vexing Problem. Front. Neurol. 4 PMID: 24151487 Pottiez et al (2017) Mass-Spectrometry-Based Method To Quantify in Parallel Tau and Amyloid β 1–42 in CSF for the Diagnosis of Alzheimer’s Disease. J. Proteome Res. 16(3) 1228 PMID: 28112948 Šimić et al (2016) Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies. Biomolecules 6(1) 6 PMID: 26751493 |
| Molecular Weight | 1402.6 |
| Sequence (One-Letter Code) | SGYSSPGSPGTPGS-[U-13C6,15N4-Arg] |
| Sequence (Three-Letter Code) | Ser-Gly-Tyr-Ser-Ser-Pro-Gly-Ser-Pro-Gly-Thr-Pro-Gly-Ser-[U-13C6,15N4-Arg]-OH |
Tau (195-209) HeavyAdmin2021-01-17T08:20:25+00:00
