| Product Name | Tau (260–267) Heavy |
| Purity | HPLC>95% |
| Description | Tubulin-related unit (tau) residues 260-267. This region represents the death-associated protein kinase 1 (DAPK1) binding domain in the tau microtubule repeat domain (R). DAPK1 phosphorylates tau on ser262 in ischemic brain injury. The peptide can block the interaction between DAPK1 and tau and reduce the level of phosphorylation of ser262, so it may have therapeutic benefits. Tau is a phosphoprotein involved in the assembly and stability of microtubules (MT) and brain development. Tau is phosphorylated by a variety of protein kinases at multiple sites, including cyclic AMP-dependent protein kinase and type 1 casein kinase. Tau phosphorylation causes tau to change shape, thereby negatively modulating its ability to stimulate MT assembly. The malfunctioning tau protein contributes to the structural core of the paired helical filaments (PHF) that make up the neurofibrillary tangles (NFT). NFT is frequently observed in neurodegenerative diseases such as Alzheimer's disease and other diseases. The lysine residue at position 8 of this peptide is isotopically labeled with carbon 13 (6) and nitrogen 15 (2) isotopes. Compared with the unlabeled peptide, the mass of the peptide is increased by 8 |
| Storage | -20°C |
| References | Gendreau and Hall G (2013) Tangles, Toxicity, and Tau Secretion in AD – New Approaches to a Vexing Problem. Front. Neurol. 4 PMID: 24151487 Pei et al (2015) A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau. Cereb Cortex 25(11) 4559 PMID: 25995053 Šimić et al (2016) Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies. Biomolecules 6(1) 6 PMID: 26751493 |
| Molecular Weight | 868.5 |
| Sequence (One-Letter Code) | IGSTENL-[U-13C6,15N2-Lys]-acid |
| Sequence (Three-Letter Code) | H-Ile-Gly-Ser-Thr-Glu-Asn-Leu-[U-13C6,15N2-Lys]-OH |
Tau (260–267) HeavyAdmin2021-01-17T07:31:45+00:00
