| Product Name | Insulin B (9-23) |
| Purity | HPLC>95% |
| Description | The insulin b-chain peptide binds to the class II histocompatibility complex (MHC) allele I-Ag7. Many autoimmune diseases are related to class II proteins encoded by MHC. Type 1 diabetes, or insulin-dependent diabetes, is a T-cell-mediated disease that causes autoimmunity to destroy pancreatic cells, leading to high blood sugar. This insulin B peptide may be a self-antigen candidate and may cause disease. Immunization of mice with this peptide can cause autoantibodies and meningitis. |
| Storage | -20°C |
| References | Devendra, D. et al. Diabetes 54, 2549 (2005). Starwalt, S. et al. Protein Eng. 16, 147 (2003); Lee, L. et al. PNAS 102, 15995 (2005). |
| Molecular Weight | 1645.9 |
| Sequence (One-Letter Code) | SHLVEALYLVCGERG |
| Sequence (Three-Letter Code) | H - Ser - His - Leu - Val - Glu - Ala - Leu - Tyr - Leu - Val - Cys - Gly - Glu - Arg - Gly - OH |
Insulin B (9-23)Admin2021-01-07T08:48:46+00:00
