| Product Name | [FAM-Trp31]-GLP-1 (7-36), Fluorescent label at Trp31 |
| Purity | HPLC>95% |
| Description | This GLP-1(7-36) amide peptide is fluorescently labeled with fluorescein at 25 tryptophan residues. This is the same type of fluorescent label as Extendin-4 Flex peptide. GLP-1(7-36)amide is an insulin-stimulating hormone that can cause glucose-dependent release of insulin by pancreatic cells. It is a cleavage product of GLP-1(1-36) amide peptide. GLP-1 (7-36) and GLP-1 (7-37) are also involved in gastric motility (gastric emptying), suppression of plasma glucagon levels (glucose production), and may promote the periphery without the action of insulin Tissues play a role in satiety and stimulation of glucose processing. GLP-1(7-36) has a short half-life of less than 2 minutes. Like GIP, it can be rapidly degraded by dipeptidyl peptidase IV (DPP-4) and is widely expressed in many sites, including endothelial cells in small intestinal arteries. . DPP-4 degrades GLP-1 (7-36) into non-insulin GLP-1 (9-36) (some studies indicate that it may have weak insulin activity). As a result, the vast majority of GLP-1 (and GIP) are inactivated as insulin growth promoters before entering the systemic circulation. |
| Storage | -20°C |
| References | Chicchi, G. G. et al. Peptides 18, 319 (1997) Drucker, D. et al. Proc Natl Acad Sci USA 84, 3434 (1987) Kieffer, T. and J. Habener, Endo Rev 20, 876 (1999) Deacon, CF. et. al. Hormone Metab Res 36,761 (2004), doi: 10.1055/s-2004-826160 Williams, JA. Pancreadepedia (2014), doi: 10.3998/panc.2014.7 Elahi, D. et. al. Obesity (Silver Spring) 16, 1501 (2008), doi: 10.1038/oby.2008.229 Ban, K. et. al. Endocrinol 151, 1520 (2010), doi: http://dx.doi.org/10.1210/en.2009-1197 |
| Molecular Weight | 3717.5 |
| Sequence (One-Letter Code) | HAEGTFTSDVSSYLEGQAAKEFIA (Trp-S-FAM)-LVKGR-NH2 |
| Sequence (Three-Letter Code) | H - His - Ala - Glu - Gly - Thr - Phe - Thr - Ser - Asp - Val - Ser - Ser - Tyr - Leu - Glu - Gly - Gln - Ala - Ala - Lys - Glu - Phe - Ile - Ala - (Trp - S - FAM) - Leu - Val - Lys - Gly - Arg - NH2 |
[FAM-Trp31]-GLP-1 (7-36), Fluorescent label at Trp31Admin2021-01-07T06:51:55+00:00
